Research-stage

SIGNA

Tracking depressive state and treatment response from wearable data.

A research-stage platform exploring how everyday wearable data can support continuous, objective tracking of depression and treatment response between clinical appointments.

SIGNA patient app concept: continuous depression monitoring from your wrist or through manual entry
The Problem

Mental health care has a visibility gap.

Mental health assessments often take place weeks or months apart. Important changes in sleep, activity, physiology, symptoms, and treatment response can occur between appointments. By the time these changes are discussed during a clinical appointment, opportunities for earlier support may already have been missed.

1–3 months
Typical gap between treatment-response assessments
~50%
Of patients may disengage from treatment over time
The challenge is not only collecting data. It is understanding meaningful change over time.
The Opportunity

Wearables already capture meaningful health signals.

Wearable devices collect health and behavioural data every day. SIGNA explores how these signals may contribute to more continuous and objective monitoring of mental health between clinical assessments.

Heart Rate Variability

Patterns in heart rate variability may provide useful physiological context.

Sleep Patterns

Sleep duration, quality, and disruption may reflect important changes over time.

Activity Levels

Daily movement and routines can provide additional behavioural signals.

Physiological & Behavioural Trends

SIGNA explores patterns across multiple signals rather than relying on a single measure.

The SIGNA Approach

Continuous insight between appointments.

SIGNA analyzes wearable-derived physiological and behavioural patterns to explore changes associated with depressive states and treatment response. The platform is being developed to generate objective, longitudinal insights that may support more proactive and personalized mental health care.

1

Wearable Device

2

Physiological & Behavioural Signals

3

SIGNA Analysis Engine

4

Treatment-Response Monitoring

5

Clinician Dashboard

SIGNA clinician dashboard concept showing longitudinal trend monitoring over 30 days

Designed to support clinical monitoring, not replace clinical judgement.

Research

Built on early research.

Early findings suggest wearable-derived physiological patterns may help distinguish depressive states from healthy controls, providing a foundation for continued research.

49
Pilot-study participants
28
Days of monitoring
187
Physiological features analyzed
SIGNA is still in research and validation. Further work is needed before real-world clinical use.
The Team

The people behind SIGNA.

The SIGNA team at EVOLVED in Toronto

Built by The Alpha Nova, with clinical guidance from Prof. Dr. Steffen Moritz (University of Hamburg).

Get Involved

Join the SIGNA waitlist.

Be among the first to hear about SIGNA's progress and early beta access.

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Interested in learning more about SIGNA?

SIGNA is currently under development and is intended for research and future clinical decision-support purposes. It is not intended to diagnose, treat, cure, or prevent any medical condition.